Proceedings title: Polymer Preprints, Japan
Volume number: 51

Abstract: Molecular imprinting technique has been developed in the design of new polymer catalysts. Recently, it is predicted that artificial polymer which recognize specific molecules just as enzyme can be prepared by introducing various interactions into the polymer. Thus, in this paper, we report synthesis of less cross-linked molecularly imprinted polymer catalyst with by using the monomers containing peptide structure in side chain. Transition state analogue (TSA) for hydrolysis of the p-nitrophenyl acetate was prepared by the reaction of p--nitrophenol with methylphosphonic dichloride. The novel functional monomers were synthesized from the amino acid (Ser, Gly, His and Phe) derivatives and acryloyl chloride. The design of monomers was inspired by the active site structure of the enzyme, a-chymotrypsin. The imprinted polymer was prepared by radical polymerization of functional monomers (N-acryloylpeptide derivatives) with small amount of cross-linker in the presence of TSA in DMSO for 24h at 0°C. Catalytic activity of the obtained polymer for the hydrolysis of p-nitrophenyl acetate is examined.

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