Abstract: In this work, a new post chemiluminescence (PCL) reaction of the Dipyridamole in the potassium fenicyanide-luminol system was found. A possible PCL mechanism was proposed based upon the studies of the kinetics characteristics, the CL spectra, fluorescence spectra of some relative reactions and other series of experiments. At the same time, Dipyridamole-imprinted polymer(MIP) was synthesized. Using the MIP as the recognition material and employing potassium ferricyanide-luminol-Dipyridamole PCL system, a new molecular imprinting-post-chemilumineseence(MIP-PCL) method for the determination of Dipyridamole was established. The linear range of this method was 1.0 x 10(-8)-1.0 x 10(-6) g/mL with a linear correlation coefficient of 0.9992, the detection limit was 3 x 10(-9) g/mL and the relative standard deviation for the determination of 1.0 x 10(-7) g/mL Dipyridamole solution was 2.7% (n=11). This method was successfully applied to the determination of Dipyridamole in human urine with a satisfactory result
Template and target information: dipyridamole
Author keywords: post-chemiluminescence, molecular imprinting, flow injection, dipyridamole

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