Abstract: An enantioselective chitosan (CS)/γ-glycidoxypropyltrimethoxysilane (GPTMS) hybrid membrane was prepared in aqueous phase by a modified sol-gel process using CS as bulk polymer, l-phenylalanine (l-Phe) as imprinting molecules and GPTMS as crosslinking agent. SEM-EDX characterization reveals the dense structure of the membrane and homogeneous distribution of silica in chitosan matrix. The chiral separation ability of CS/GPTMS hybrid molecularly imprinted membranes towards the underivatized d,l-Phe aqueous mixture was evaluated by permeation and binding experiments. Significantly improved selectivity with a separation factor αd/l up to 4.5 has been achieved
Template and target information: Lphenylalanine, L-Phe
Author keywords: Hybrid molecularly imprinted membrane, chitosan, GPTMS, chiral resolution, d,l-Phenylanaline

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