Abstract: A luminol-potassium ferricyanide-perphenazine CL reaction with high sensitivity for the determination of perphenazine was found. A perphenazine molecular imprinted polymer (MIP) was synthesized. Using the perphenazine MIP as a recognition material, a novel molecular imprinting-chemiluminescence (MI-CL) sensor for the determination of perphenazine was made based on the luminol-potassium ferricyanide-perphenazine CL reaction. The sensor displayed good selectivity and high sensitivity. The linear-response range of the sensor was 5.0x10(-8)-1.0x10(-5) g/ml with a linear correlation coefficient of 0.9961. The detection limit was 2x10(-8) g/ml perphenazine and the relative standard deviation for 1.0x10(-6) g/ml perphenazine solution was 3.7% (n=11). The sensor was applied to the determination of perphenazine in urine samples with satisfactory results
Template and target information: perphenazine

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