Abstract: Metal-complexing imprinted polymer for L-mandelic acid was prepared using Cu(II)-[N-(4-vinylbenzyl)]iminodiacetic acid as functional monomer, trimethylolpropane trimethacrylate as crosslinker and methanol as porogenic agent. Chiral separation ability of metal-complexing imprinted polymer to D,L-mandelic acid was investigated by high performance liquid chromatography. The mobile phase conditions (pH, methanol content, buffer concentration, etc.) could significantly influence the chiral separation ability of metal-complexing imprinted polymer. Highly chiral selective to the template molecule by metal-complexing imprinted polymer was achieved as pH 7-9 of the mobile phase; the chiral separation ability of metal-complexing imprinted polymer was increased with the increase of methanol content and buffer concentration. It is suggested the feasibility to prepare highly selective molecularly imprinted polymer in polar solvent
Template and target information: L-mandelic acid
Author keywords: chiral separation, mandelic acid, metal coordination-chelation interaction, molecularly imprinted polymer

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