Abstract: Binding or catalysis? Both can be distinguished with a molecularly imprinted polymer (MIP) by the different patterns of heat generation. The catalytically active sites, like in the corresponding enzyme, generate a steady-state temperature increase. Thus, enzyme-like catalysis and antibody-analogue binding are analyzed simultaneously in a bifunctional MIP for the first time (see scheme).
Template and target information: (4-Aminobenzyl)-phosphoramidic acid-4-nitrophenylester, phenylacetate, PA, nitrophenylacetate, NPA
Author keywords: Biosensors, calorimetry, enzyme models, molecular recognition, solvolysis

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