Abstract: Herein the preparation of molecularly imprinted polymers (MIPs) using supercritical fluid technology is evaluated. Poly(diethylene glycol dimethacrylate), polyDEGDMA, was synthesised in supercritical carbon dioxide (scCO2) using a carboxylic acid end-capped perfluoropolyether oil as stabiliser. Polymerisations were carried out in the presence of different concentrations of two different template drug molecules, salicylic acid and acetylsalicylic acid. Results suggest that molecular imprinted polymers were successfully prepared by supercritical polymerisation and then impregnated with the template in order to prepare controlled release systems
Template and target information: salicylic acid, acetylsalicylic acid, 2-hydroxybenzoic acid, aspirin
Author keywords: molecular imprinting, polymerisation, Impregnation, Supercritical carbon dioxide, Diethylene glycol dimethacrylate, cross-linking

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