Abstract: Molecularly imprinted polymer of metformin was synthesized and a chemiluminescence sensor was prepared using the polymer as recognition material for the determination of metformin.NBS and fluorescein reacted with metformin to produce strong CL.The CL intensity was linear to metformin concentration in the range from 2×10~(-8) to 8×10~(-6) g/mL.The detection limit was 6×10~(-9) g/mL and the R.S.D.was less than 5%(n=7).The selective experiment showed that it could greatly improve the selectivity of CL method when MIP was applied to CL.The sensor was reversible and could be used for more than 100 times.It has been used to determine the metfomin in human urine samples.
Template and target information: metformin
Author keywords: molecularly imprinted polymer, chemiluminescence, sensor, metformin

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