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Reference type: Journal
Authors: Zhang CL, Zhou YM, Lei JD, Ma TS, Ma GH, Su ZG
Article Title: Synthesis of molecularly imprinted polymer for Rifampicin and its adsorption.
Publication date: 2009
Journal: The Chinese Journal of Process Engineering
Volume: 9
Issue: (3)
Page numbers: 608-612.
Alternative URL: http://www.bfbm.cn/uploadfiles/paper/2009/21.pdf

Abstract: Molecularly imprinted polymer was synthesized with Rifampicin (RFP) as template molecule, methacrylic acid'as functional monomers and ethylene dimethacrylate as crosslinker. The polymer was investigated in equilibrium binding experiment and Scatchard analysis to evaluate the binding characteristics and recognition mechanism of RFP molecular imprinted polymer in aqueous solution. Scatchard analysis showed that two classes of binding sites were produced in the polymer matrix under the studied concentration. Their dissociation constant (Kd) and apparent maximum binding capacity (Qmax) were Kd1=31.5 mg/mL, Qmax1=23.34 mg/g for high affinity binding sites and Kd2=9.22 mg/mL, Qmax2=12-86 mg/g for low affinity binding sites. The binding experiments of different substrates showed that the imprinted polymers possessed tailor-made recognition sides for RFP
Template and target information: Rifampicin, RFP
Author keywords: molecular recognition, molecularly imprinted polymer, rifampicin, selectivity

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