Abstract: The present work describes a new, simple, and easy method for the generation of stable molecularly imprinted sites in polymeric film, combining self-assembled monolayer and Layer-by-layer approaches through thermal cross-linking of the layered structures, onto the surface of silver electrode. Modified silver electrodes demonstrate enantiodifferentiation and sensitive (detection limits 0.0060 ng mL-1 for l- and 0.0062 for d-thyroxine) determination of d- and l-thyroxine with the help of differential pulse anodic stripping voltammetric technique. The binding kinetics of thyroxine was explored using anodic stripping cyclic voltammetry and chronocoulometry. The sensor was also validated for d- and l-thyroxine determinations in biological and pharmaceutical samples
Template and target information: thyroxine, l-thyroxine, d-thyroxine
Author keywords: Layer-by-layer, self-assembled monolayer, molecularly imprinted polymer, d- and l-Thyroxine, enantioselectivity

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