Abstract: In this paper, highly selective core-shell molecularly imprinted polymers of 17β-estradiol on the surface of silica nanoparticles (SiO2@E2-MIPs) were prepared. The SiO2@E2-MIPs were characterized by Fourier transform infrared spectrometer (FT-IR), transmission electron microscope (TEM), dynamic adsorption and static adsorption tests. The sorption capacity of the SiO2@E2-MIPs were nearly 5 times that of the non-imprinted polymers (NIPs), and it only took 25 min to achieve the sorption equilibrium. It indicated that the SiO2@E2-MIPs exhibited a high selectivity, large adsorption capacity and fast kinetics. When the SiO2@E2-MIPs were used as dispersive solid-phase extraction (dSPE) absorbents to selectively enrich and determine estrogens in duck feed, the average recoveries of E2 and estriol (E3) were higher than 96.74% and 72.07%, respectively, and the relative standard deviations (RSD) of E2 and E3 were less than 1.61% and 3.28%, respectively. The study provides an effective method for the separation and enrichment of estrogens in the complex matrix samples by the SiO2@E2-MIPs
Template and target information: 17β-estradiol
Author keywords: 17β-estradiol, estrogens, Molecularly imprinted polymers, silica nanoparticles, Dispersive solid-phase extraction, Feed

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