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Reference type: Journal
Authors: Jafari MT, Rezaei B, Javaheri M
Article Title: A new method based on electrospray ionisation ion mobility spectrometry (ESI-IMS) for simultaneous determination of caffeine and theophylline.
Publication date: 2011
Journal: Food Chemistry
Volume: 126
Issue: (4)
Page numbers: 1964-1970.
DOI: 10.1016/j.foodchem.2010.12.054
Alternative URL: http://www.sciencedirect.com/science/article/B6T6R-51PRYG3-4/2/c37504bd82d10d4f580af3c6d493459f

Abstract: In this work for the first time, simultaneous analysis of caffeine and theophylline was done by ion mobility spectrometry (IMS) only, without a powerful separation technique (e.g., HPLC). Ion mobility spectrometry with low cost, inexpensive maintenance and very fast analysis makes an attractive technique for the simultaneous determination of the caffeine and theophylline in foodstuff samples and biological matrices. In this study, the extraction protocol using molecular imprinted polymer-solid phase extraction (MIP-SPE) was successfully used to directly extract caffeine and theophylline from real samples. The results obtained provided the detection limits of 0.2 and 0.3 μg mL-1 for caffeine and theophylline, respectively. The linear dynamic range of about two orders of magnitude was obtained for these compounds. Also, the proposed method was used to analyse various real samples of green tea and spiked human plasma, and the obtained results confirmed the capability of ESI-IMS for simultaneous detection of caffeine and theophylline
Template and target information: caffeine, theophylline
Author keywords: Simultaneous analysis, caffeine, theophylline, ion mobility spectrometry

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