Abstract: The design and construction of a highly selective voltammetric sensor for metronidazole by using a molecularly imprinted polymer (MIP) as recognition element were introduced. A metronidazole selective MIP and a nonimprinted polymer (NIP) were synthesized and then incorporated in the carbon paste electrodes (CPEs). The sensor was applied for metronidazole determination using cathodic stripping voltammetric method. The MIP-CP electrode showed very high recognition ability in comparison to NIP-CPE. Some parameters affecting the sensor response were optimized and then the calibration curve was plotted. Two dynamic linear ranges of 5.64 x 10-5 to 2.63 x 10-3 mg L-1 and 2.63 x 10-3 to 7.69 x 10-2 mg L-1 were obtained. The detection limit of the sensor was calculated as 3.59 x 10-5 mg L-1. This sensor was used successfully for metronidazole determination in biological fluids
Template and target information: metronidazole
Author keywords: Metronidazole, molecularly imprinted polymer, Cathodic stripping voltammetry, Carbon paste

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