Abstract: Molecularly imprinted polymers (MIPs) are tailor-made polymers with high selectivity for a given analyte, or group of structurally related compounds. The influence of the process parameters (the moles of functional monomer and cross-linker, the selection of functional monomer and solvent) on the preparation of oseltamivir (OS)-imprinted polymers was investigated. A mathematical method for uniform design to optimize these selected parameters and to increase the MIP selectivity for template molecules was applied. The optimal conditions to synthesize MIP were 0.69mmol 30% acrylamide (AA) + 70% 4-Vinylpyridine (4-VP) and 5.0mmol ethylene glycol dimethacrylate (EGDMA) copolymerized in 5ml toluene in the presence of 0.1mmol OS. MIP showed high affinity and selectivity for separation of the template molecule from other compounds. In the present study, we have established an effective LC-MS/MS method to identify and quantify OS with good sensitivity, accuracy and precision
Template and target information: oseltamivir, OS
Author keywords: molecularly imprinted polymer (MIP), Polymerization optimization, selectivity, Uniform design, Oseltamivir, LC-MS, MS

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