Abstract: A three-dimensionally ordered,macroporous,inverse-opal glucose molecularly imprinted polymer crystal(MIPC) film was synthesized by the inverted colloidal-crystal template technique.Preparation of our MIPC was carried out by thermo-poymerization of monomers(2-hydroxyethyl methacrylate and N-isopropylacrylamide),covalent recognizer(4-ethylenyl phenylboronic acid),and cross-linker(N,N'-Methylenebisacrylamide) with poly(methyl-methacrylate)(PMMA) particle array as template,followed by chemical removal of the template using acetone.Due to its 3D-ordered macroporous arrays with molecular imprinting,nanocavities,the formed photonic hydrogel allows rapid and selective detection of the target glucose.The glucose adsorption amount of our MIP was 3.2 mg/g in 3 min which is two times more than that of other analogues.The diffraction wavelength of the MIPC redshifts was more than 150 nm in response to 0.02 mol/L of glucose.Our results revealed that MIPC could provide a novel non-invasive approach for glucose detection in tears or urine and exhibit a promising potential for development of new glucose monitoring technology.
Author keywords: photonic crystals, molecular imprinting, Glucose detection, self-assembly

Tweet