Abstract: A photo-responsive molecularly imprinted sol-gel organic-inorganic hybrid material prepared by covalent imprinting of the template-functional monomer complex formed between 4,4'-dihydroxylazobenzene and ibuprofen was developed to explore the photo-regulated uptake and release of drug by a silicate-based smart molecularly imprinted materials. After imprinting, the template molecules (ibuprofen) were removed via hydrolysis in acid, and accurate cavities were left, which could be used as the receptor recognition sites for ibuprofen. The new organic-inorganic hybrid material shows specific affinity to ibuprofen and reversible uptake and release of ibuprofen upon alternate irradiation at 365 and 440 nm, respectively. The favorable binding strength of the imprinted receptor sites in the molecularly imprinted polymer (MIP) for ibuprofen is found to be 2.28 x 10 3 M-1 . Density of receptor sites in the MIP material was 4.0 μmol/g-MIP
Template and target information: ibuprofen
Author keywords: sol-gel, Organic-inorganic hybrid materials, ibuprofen, Photo-responsive, Azobenzene

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