Abstract: Enantioselective trace level sensing of l-histidine (limit of detection, 1.980 ng mL-1, S/N = 3) was feasible with the use of a typical, reproducible, and rugged complex imprinted polymer-based pencil graphite electrode, in aqueous samples. In the present instance, the Cu2+ ion-mediated imprinting of l-histidine in an molecularly imprinted polymer motif actually helped upbringing electrocatalytic activity to respond an enhanced differential pulse anodic stripping voltammetric oxidation peak of l-histidine, without any cross-reactivity and false-positive, in real samples. The proposed sensor could be considered suitable for the practical applications in biomarking histedinemia, a disease associated with l-histidine metabolic disorders, in clinical settings
Template and target information: L-histidine
Author keywords: Metal-ion mediated imprinting, L-Histidine, "Grafting-from" approach, iniferter, Differential pulse anodic stripping voltammetry

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