Abstract: In the present work a novel potentiometric sensor, based on a noncovalent imprinted polymer, was developed for determination of Lamotrigine (LTG). At optimized conditions the electrode exhibited a Nernstian response (30.8 ± 1.0 mV decade-1) in a concentration range of 1 x 10-6 to 1 x 10-3 M with a detection limit of 8 x 10-7 mol L-1. The potential response of the electrode was constant in the pH range of 1.0 - 5.0. The electrode demonstrated a response time of ~30 s. The selectivity coefficient of the sensor toward a number of different drugs with molecular similarities and some metal ions was evaluated. The electrode was examined for determination of LTG in real samples
Template and target information: lamotrigine, LTG
Author keywords: Molecularly imprinted polymers, Potentiometric sensors, Lamotrigine

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