Abstract: Molecularly imprinted polymers(MIPs) were synthesized by bulk polymerization and swelling polymerization using nicotinic acid(NA) as the imprinted molecule,4-vinylpyridine(4-VP) as the functional monomer and ethyleneglycol dimethacrylate(EGDMA) as the cross-linker,initiated thermally with azobisisobutyronitrile(AIBN).The binding and selectivity of MIPs to NA and different substrates were evaluated by the static batch method.The adsorption amounts of MIP1 and MIP2 were 193.56 μmol/g and 215.35 μmol/g,respectively,which were obviously higher than those of their corresponding non-imprinted polymers,NIP1 and NIP2.The adsorption capacity of niacinamide on MIPs was the largest,followed by benzoic acid,benzyl alcohol and 3-pyridine methanol.The results indciated that the stereostructure of the substrate and the interactions between substrate and imprinting bites influenced the recognition property of MIPs.
Template and target information: nicotinic acid, NA
Author keywords: Molecularly imprinted polymers, Nicotinic acid, mechanism of recognition, Bulk polymerization, swelling polymerization

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