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Reference type: Journal
Authors: Findeisen A, Wackerlig J, Samardzic R, Pitkänen J, Anttalainen O, Dickert FL, Lieberzeit PA
Article Title: Artificial receptor layers for detecting chemical and biological agent mimics.
Publication date: 2012
Journal: Sensors and Actuators B: Chemical
Volume: 170
Page numbers: 196-200.
DOI: 10.1016/j.snb.2011.08.025
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0925400511007489

Abstract: Dimethyl methylphosphonate (DMMP) and Escherichia coli are mimics for chemical and biological agents, respectively. For designing robust sensor systems aiming at detecting them in real-life indoor environments, we designed artificial receptors based on bulk and surface imprinted polymers, respectively. Bulk-imprinted artificial recognition materials for DMMP yielded detection limits of 0.2 ppm in air on quartz crystal microbalance (QCM) sensor with selectivity factors of > 40 towards indoor background contaminants, such as alcohols or acetic esters. The sensor layers retain their sensitivity for at least one year thus showing potential for maintenance-free long term sensing. They can be combined with pre-concentrator units to increase the overall performance of the system. Surface-imprinted polyurethanes optimized to selectively recognize E. coli showed ten times higher sensor responses on QCM than the respective non-imprinted polymers. Detection limits of these sensors turned out to be in the range of 0.1 mg/ml E. coli in aqueous solution. Different strains of this species (b and w, respectively) could be discriminated with selectivity factors of at least three thus implementing bioanalogous recognition in robust, man-made materials
Template and target information: dimethyl methylphosphonate, DMMP, bacteria, Escherichia coli
Author keywords: molecular imprinting, DMMP, E.Coli, QCM, Real-life applications

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