Abstract: A novel molecularly imprinted electrochemical sensor based on Fe3O4@Au nanoparticles immobilized on amine-multi-walled carbon nanotubes by the strong chemisorption had been developed for detecting dipyridamole (DIP) in human serum using precipitation polymerization method. DIP can be detected by this electrochemical sensor through the response current change before and after binding DIP with the formation of hydrogen bonds. The experimental binding data for this study was modeled with the Freundlich isotherm (FI) equation, demonstrating the high imprinting efficiency. The molecularly imprinted electrochemical sensor based on Fe3O4@Au-MWCNT nanocomposite amplifies the response current in differential pulse voltammetry measurement, allowing the detection limit reaching 0.03 ng mL-1 in a wide linear range from 0.5 to 1900 ng mL-1, which is remarkably better than those of currently used methods and the previous reports. Moreover, this molecularly imprinted electrochemical sensor has first been developed for the detection of DIP based on the Fe3O4@Au-MWCNT composite, which has a promising potential in the detection of DIP in human serum which enables low-cost, effective, and sensitive determination
Author keywords: Molecularly imprinted polymer, Freundlich isotherm, electrochemical sensor, Dipyridamole