Publisher: Springer
City: Berlin, Heidelberg
ISBN: 1612-7617

Abstract: Molecularly imprinted polymers (MIPs) have been prepared mostly for low-molecular-weight biomarkers and drugs but also for a spectrum of proteins. As compared with antibodies, MIPs have higher chemical and thermal stability, and they can be regenerated for repeated measurements. Electrochemical methods dominate the read-out of MIP sensors. Many protein MIPs have been tested in artificial urine or spiked semi-synthetic plasma, and point-of-care detection of marker proteins e.g. for cardiac, cancer, Alzheimer's disease or virus infections is the prospective aim. In the following chapter, the preparation and analytical performance of a broad spectrum of MIP sensors for protein biomarker are presented. The examples are grouped according to the respective diseases. For the majority of biomarkers, different approaches of sensor preparation and signal read-out can be compared
Author keywords: biomimetic sensors, Electropolymerization, Molecularly imprinted polymers, Protein biomarkers, protein imprinting