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Reference type: Journal
Authors: Sasaki DY, Alam TM
Article Title: Solid-state 31P NMR study of phosphonate binding sites in guanidine-functionalized, molecular imprinted silica xerogels.
Publication date: 2000
Journal: Chemistry of Materials
Volume: 12
Issue: (5)
Page numbers: 1400-1407.
DOI: 10.1021/cm990737r

Abstract: Phosphonate binding sites in guanidine and ammonium surface- functionalized silica xerogels were prepared via the molecular imprinting technique and characterized using solid-state P-31 MAS NMR. One-point, two-point, and nonspecific host-guest interactions between phenylphosphonic acid (PPA) and the functionalized gels were distinguished by characteristic chemical shifts of the observed absorption peaks. Using solid- state as well as solution-phase NMR analyses, absorptions observed at 15.5 and 6.5 ppm were identified as resulting from the 1:1 (one-point) and 2:1 (two-point) guanidine to phosphonate interactions, respectively. Similar absorptions were observed with the ammonium functionalized gels. By examining the host-guest interactions within the gels, the efficiency of the molecular imprinting procedure with regard to the functional monomer-to-template interaction could be readily assessed. Template removal followed by substrate adsorption studies conducted on the guanidine-functionalized gels provided a method to evaluate the binding characteristics of the receptor sites to a phosphonate substrate. During these experiments, Si-29 and P-31 MAS NMR acted as diagnostic monitors to identify structural changes occurring in the gel matrix and at the receptor site from solvent-mediated processes

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