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Reference type: Journal
Authors: Culver HR, Daily AM, Khademhosseini A, Peppas NA
Article Title: Intelligent recognitive systems in nanomedicine.
Publication date: 2014
Journal: Current Opinion in Chemical Engineering
Volume: 4
Page numbers: 105-113.
DOI: 10.1016/j.coche.2014.02.001
Alternative URL: http://www.sciencedirect.com/science/article/pii/S2211339814000252

Abstract: There is a bright future in the development and utilization of nanoscale systems based on intelligent materials that can respond to external input providing a beneficial function. Specific functional groups can be incorporated into polymers to make them responsive to environmental stimuli such as pH, temperature, or varying concentrations of biomolecules. The fusion of such 'intelligent' biomaterials with nanotechnology has led to the development of powerful therapeutic and diagnostic platforms. For example, targeted release of proteins and chemotherapeutic drugs has been achieved using pH-responsive nanocarriers while biosensors with ultra-trace detection limits are being made using nanoscale, molecularly imprinted polymers. The efficacy of therapeutics and the sensitivity of diagnostic platforms will continue to progress as unique combinations of responsive polymers and nanomaterials emerge
Template and target information: Review - nanomedicine


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