Authors: Sellergren B
, Ekberg B
, Mosbach K
Molecular imprinting of amino-acid derivatives in macroporous polymers - demonstration of substrate-selectivity and enantio-selectivity by chromatographic resolution of racemic mixtures of amino-acid derivatives.
Publication date: 1985
Journal: Journal of Chromatography
Abstract: Substrate-selective macroporous polymers were prepared by a non-covalent imprinting procedure. By this method, acrylic polymers selective for D or L-phenylalanine ethyl esters were prepared utilizing coulombic interactions, during polymerization, between the print molecule ( D or L-phenylalanine ethyl ester) and the carboxyl group carried by the vinyl monomers. These polymers, after removal of print molecules, were used in a chromatographic procedure to examine their enatio- and substrate-selectivity for some amino acid derivatives. The best separation factor, a, for D,L-phenylalanine ethyl ester was found to be 1.30. The selectivity persisted to several months after intermittent applications.
Join the Society for Molecular Imprinting
New items RSS feed
View latest updates
Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent
to go to the sign-up page.
Is your name elemental
? Enter your name and find out by clicking either of the buttons below!
Other products you may like: