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Reference type: Journal
Authors: Berglund J, Nicholls IA, Lindbladh C, Mosbach K
Article Title: Recognition in molecularly imprinted polymer a2-adrenoreceptor mimics.
Publication date: 1996
Journal: Bioorganic & Medicinal Chemistry Letters
Volume: 6
Issue: (18)
Page numbers: 2237-2242.
DOI: 10.1016/0960-894X(96)00406-4

Abstract: Molecularly imprinted polymers (MIPs) selective for the alpha(2)- adrenoreceptor antagonist yohimbine (1) have been prepared and studied as alpha(2)-adrenoreceptor mimics. Marked ligand stereoselectivity was demonstrated in radioligand binding and HPLC studies upon comparison to blank and corynanthine (2) MIPs. K-D values in the nanomolar range have been shown for anti-1 MIP prepared in chloroform solutions upon rebinding in organic media. Copyright (C) 1996 Published by Elsevier Science Ltd


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