Book title: Molecular and Ionic Recognition with Imprinted Polymers
Editors: Bartsch RA, Maeda M
Publisher: The American Chemical Society
City: Washington DC
Series title: ACS Symposium Series
Volume number: 703
Abstract: Receptor sites capable of distinguishing between molecules having minor structural differences can be prepared by noncovalent imprinting of templates in network polymers. Initially, these polymers are prepared considering functional group complementarity between a functional monomer and the template. The performance of these ,,first generation" materials is often unacceptable and a careful optimization of the variables in the imprinting process is therefore needed in order to reach the desired level of affinity and selectivity for the target compound. Depending on the separation requirements, the imprinted materials are further associated with problems, i.e. non-linear adsorption isotherms, strong medium dependence, slow mass transfer kinetics and a low sample load capacity, that may need to be solved. In this review some guidelines for achieving the desired level of recognition is given based on the existing knowledge of noncovalent imprinting.