MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Turco A, Corvaglia S, Mazzotta E
Article Title: Electrochemical sensor for sulfadimethoxine based on molecularly imprinted polypyrrole: Study of imprinting parameters.
Publication date: 2015
Journal: Biosensors and Bioelectronics
Volume: 63
Page numbers: 240-247.
DOI: 10.1016/j.bios.2014.07.045
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0956566314005466

Abstract: The present work describes the development of a simple and cost-effective electrochemical sensor for sulfadimethoxine (SDM) based on molecularly imprinted overoxidized polypyrrole (PPy). An all electrochemical approach is used for sensor fabrication and application consisting in molecularly imprinted polymer (MIP) galvanostatic deposition on a gold electrode and its overoxidation under different experimental conditions and in SDM amperometric detection. Several parameters influencing the imprinting effect are critically discussed and evaluated. A key role of the electrolyte used in electropolymerization (tetrabuthylammonium perchlorate and lithium perchlorate) has emerged demonstrating its effect on sensing performances of imprinted PPy and, related to this, on its morphology, as highlighted by atomic force microscopy (AFM). The effect of different overoxidation conditions in removing template is evaluated by analyzing MIP films before and after the treatment by X-ray photoelectron spectroscopy (XPS) also evidencing the correlation between MIP chemical structure and its rebinding ability. MIP-template interaction is verified also by Fourier Transform Infrared (FT-IR) spectroscopy. Under the selected optimal conditions, MIP sensor shows a linear range from 0.15 to 3.7 mM SDM, a limit of detection of 70 μM, a highly reproducible response (RSD 4.2%) and a good selectivity in the presence of structurally related molecules. SDM was determined in milk samples spiked at two concentration levels: 0.2 mM and 0.4 mM obtaining a satisfactory recovery of (97 3)% and (96 8)%, respectively
Template and target information: sulfadimethoxine, SDM
Author keywords: Electrosynthesis of molecularly imprinted polymer, Molecularly imprinted overoxidized polypyrrole, Sulfadimethoxine amperometric detection

  Eat, sleep, imprint, repeat mug  SMI logo mug  Woman of proper-tea mug in blue

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner