MIPs logo MIPdatabase     MIP2018 Conference website
Custom Search
Reference type: Journal
Authors: Pereira AV, Cervini P, Cavalheiro ETG
Article Title: Do voltammetry electrodes modified with MIPs really work? The role of large molecules: folic acid as a probe.
Publication date: 2014
Journal: Analytical Methods
Volume: 6
Issue: (17)
Page numbers: 6658-6667.
DOI: 10.1039/C4AY00616J

Abstract: There are many uncertainties concerning the use of molecularly imprinted polymers (MIPs) as electrode modifiers. In order to contribute to clarification of this issue, a large target molecule was used to prepare an MIP-modified composite electrode. The MIP was synthesized using folic acid (FA) as a template, and employed in the modification of composite electrodes based on graphite and polyurethane (GPU), varying its percentage from 2.5 to 10%. Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) were used to compare the performance of modified and unmodified electrodes. After optimization of the electrode composition, pH, and the electrolytic medium, the best results for which were obtained using 2.5% MIP, pH 4.5 and acetate buffer, respectively, differential pulse voltammograms were used to obtain analytical curves for electrodes modified with the 2.5% MIP or 2.5% non-imprinted polymer (NIP), as well as for the unmodified GPU electrode. Although the sensitivities were similar in all cases, the electrode modified with 2.5% MIP presented a lower limit of detection (LOD) of 0.17 μmol L-1 and 0.034 μmol L-1 for the cathodic peaks in -0.52 and -0.58 V (vs. SCE), respectively, under specific conditions, allowing the determination of FA in commercial pharmaceutical formulations with results that were in agreement with the official HPLC method. Finally, evaluation was made of the interference of a structurally similar molecule, the methotrexate, as well as small molecules containing functional groups similar to those present in the structure of FA, such as uric acid, ascorbic acid and dopamine. The 2.5% MIP electrode was more selective than the 2.5% NIP electrode
Template and target information: folic acid, FA


  Mister Benzene Get Well Soon card  Chemistry peptide mug  Beach bunny periodic table shirt

Molecules Special Issue call     Sensors Special Issue call






Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:
US listings   UK listings

Searching for Molecular Imprinting books on Amazon.com:
Molecular Imprinting
Imprinted Polymers
Polymer Chemistry
Organic Chemistry
Biosensors

Find what you need at Amazon.com

Lab supplies from Amazon