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Reference type: Journal
Authors: Zhang LL, Qi ZY, Huang QY, Zeng K, Sun XY, Li J, Liu YN
Article Title: Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery.
Publication date: 2014
Journal: Colloids and Surfaces B: Biointerfaces
Volume: 123
Page numbers: 15-22.
DOI: 10.1016/j.colsurfb.2014.08.033
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0927776514004561

Abstract: To enhance the solubility and improve the bioavailability of hydrophobic curcumin, a new kind of imprinted-like biopolymeric micelles (IBMs) was designed. The IBMs were prepared via co-assembly of gelatin-dextran conjugates with hydrophilic tea polyphenol, then crosslinking the assembled micelles and finally removing the template tea polyphenol by dialysis. The obtained IBMs show selective binding for polyphenol analogous drugs over other drugs. Furthermore, curcumin can be effectively encapsulated into the IBMs with 5 x 10^4-fold enhancement of aqueous solubility. We observed the sustained drug release behavior from the curcumin-loaded IBMs (CUR@IBMs) in typical biological buffers. In addition, we found the cell uptake of CUR@IBMs is much higher than that of free curcumin. The cell cytotoxicity results illustrated that CUR@IBMs can improve the growth inhibition of HeLa cells compared with free curcumin, while the blank IBMs have little cytotoxicity. The in vivo animal study demonstrated that the IBMs could significantly improve the oral bioavailability of curcumin
Template and target information: curcumin
Author keywords: Curcumin, molecular imprinting, Micelle, solubility, Oral bioavailability, drug delivery


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