MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Huynh TP, Chandra BKC, Sosnowska M, Sobczak JW, Nesterov VN, D'Souza F, Kutner W
Article Title: Nicotine molecularly imprinted polymer: Synergy of coordination and hydrogen bonding.
Publication date: 2015
Journal: Biosensors and Bioelectronics
Volume: 64
Page numbers: 657-663.
DOI: 10.1016/j.bios.2014.09.014

Abstract: Two new bis(2,2'-bithienyl)methane derivatives, one with the zinc phthalocyanine substituent (ZnPc-S16) and the other with the 2-hydroxyethyl substituent (EtOH-S4), were synthesized to serve as functional monomers for biomimetic recognition of nicotine (Nic) by molecular imprinting. Formation of a pre-polymerization complex of the Nic template with ZnPc-S16 and EtOH-S4 was confirmed by both the high negative Gibbs free energy gain, Δ G = -115.95 kJ/mol, calculated using the density functional theory at the B3LYP/3-21 G* level, and the high stability constant, Ks = 4.67 x 10^5 M-1, determined by UVGvis titration in chloroform. A solution of this complex was used to deposit a Nic-templated molecularly imprinted polymer (MIP-Nic) film on an Au electrode of a quartz crystal resonator of EQCM by potentiodynamic electropolymerization. The imprinting factor was as high as ~9.9. Complexation of the Nic molecules by the MIP cavities was monitored with X-ray photoelectron spectroscopy (XPS), as manifested by a negative shift of the binding energy of the Zn 2p3/2 electron of ZnPc-S16 after Nic templating. For sensing applications, simultaneous chronoamperometry (CA) and piezoelectric microgravimetry (PM) measurements were performed under flow-injection analysis conditions. The limit of detection of the CA and PM chemosensing was as low as 40 and 12 μM, respectively. Among them, the CA chemosensing was more selective to the cotinine and myosmine interferences due to the 1.10 V vs. Ag/AgCl discriminating potential of nicotine electro-oxidation applied. Differences in selectivity to the analyte and interferences were interpreted by modeling complexation of Nic and, separately, each of the interferences with a "frozen" MIP-Nic molecular cavity
Template and target information: nicotine, Nic
Author keywords: nicotine, molecularly imprinted polymer, chemical sensor, Electrochemical quartz crystal microbalance, Chronoamperometry

  Live and Let MIP spoof movie poster customisable greetings card  Mug featuring the name Marta spelled out in the single letter amino acid code  Chemists are fun customisable shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner