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Reference type: Journal
Authors: Takeuchi T, Mori T, Kuwahara A, Ohta T, Oshita A, Sunayama H, Kitayama Y, Ooya T
Article Title: Conjugated-Protein Mimics with Molecularly Imprinted Reconstructible and Transformable Regions that are Assembled Using Space-Filling Prosthetic Groups.
Publication date: 2014
Journal: Angewandte Chemie International Edition
Volume: 53
Issue: (47)
Page numbers: 12765-12770.
DOI: 10.1002/anie.201406852

Abstract: Conjugated-protein mimics were obtained using a new molecular imprinting strategy combined with post-imprinting modifications. An antibiotic was employed as a model template molecule, and a polymerizable template molecule was designed, which was composed of the antibiotic and two different prosthetic groups attached through a disulfide bond and Schiff base formation. After co-polymerization with a cross-linker, the template molecule was removed together with the prosthetic groups, yielding the apo-type scaffold. Through conjugation of the two different prosthetic groups at pre-determined positions within the apo-type scaffold, the apo cavity was transformed into a functionalized holo cavity, which enables the on/off switching of the molecular recognition ability, signal transduction activity for binding events, and photoresponsive activity
Author keywords: imprinting, molecular recognition, polymers, protein mimics


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