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Reference type: Journal
Authors: Manzoor S, Buffon R, Rossi AV
Article Title: Molecularly imprinted solid phase extraction of fluconazole from pharmaceutical formulations.
Publication date: 2015
Journal: Talanta
Volume: 134
Page numbers: 1-7.
DOI: 10.1016/j.talanta.2014.10.057
Alternative URL: http://www.sciencedirect.com/science/article/pii/S0039914014008856

Abstract: This work encompasses a direct and coherent strategy to synthesise a molecularly imprinted polymer (MIP) capable of extracting fluconazole from its sample. The MIP was successfully prepared from methacrylic acid (functional monomer), ethyleneglycoldimethacrylate (crosslinker) and acetonitrile (porogenic solvent) in the presence of fluconazole as the template molecule through a non-covalent approach. The non-imprinted polymer (NIP) was prepared following the same synthetic scheme, but in the absence of the template. The data obtained from scanning electronic microscopy, infrared spectroscopy, thermogravimetric and nitrogen Brunauer-Emmett-Teller plot helped to elucidate the structural as well as the morphological characteristics of the MIP and NIP. The application of MIP as a sorbent was demonstrated by packing it in solid phase extraction cartridges to extract fluconazole from commercial capsule samples through an offline analytical procedure. The quantification of fluconazole was accomplished through UPLC-MS, which resulted in LOD 1.63 x 10-10 mM. Furthermore, a high percentage recovery of 91 10% (n=9) was obtained. The ability of the MIP for selective recognition of fluconazole was evaluated by comparison with the structural analogues, miconazole, tioconazole and secnidazole, resulting in percentage recoveries of 51, 35 and 32%, respectively
Template and target information: fluconazole
Author keywords: molecularly imprinted polymer, MIP, Fluconazole


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