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Reference type: Journal
Authors: Spivak D, Shea KJ
Article Title: Molecular imprinting of carboxylic acids employing novel functional macroporous polymers.
Publication date: 1999
Journal: Journal of Organic Chemistry
Volume: 64
Issue: (13)
Page numbers: 4627-4634.
DOI: 10.1021/jo982118s

Abstract: Imprinted network polymers incorporating basic functional groups were developed to assess the binding and specificity of carboxylic acids. The binding affinities were determined using t-BOC-phenylalanine and 2-phenylbutyric acid as templates and substrates. Chiral. selectivity for the enantiomers of t-BOC-phenylalanine was found for polymers incorporating adenine or 2-aminopyridine functionality. Chiral selectivity in the case of (R)-(-)-2-phenylbutyric acid was found for the polymer utilizing N-(2-aminoethyl) methacrylamide as the functional monomer. Optimization of binding was achieved by changing polymerization conditions (thermal versus photochemical polymerization, monomer:template ratio) for t-BOC-phenylalanine imprinted polymers employing the N-(2-aminopyridine) methacrylamide monomer


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