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Reference type: Journal
Authors: Valencia Castro LE, Pérez Martínez CJ, del Castillo Castro T, Castillo Ortega MM, Encinas JC
Article Title: Chemical polymerization of pyrrole in the presence of l-serine or l-glutamic acid: Electrically controlled amoxicillin release from composite hydrogel.
Publication date: 2015
Journal: Journal of Applied Polymer Science
Volume: 132
Issue: (15)
Page numbers: Article No 41804.
DOI: 10.1002/app.41804

Abstract: Polypyrrole (PPy) was chemically prepared from aqueous solutions individually containing l-serine or l-glutamic acid, with the addition of ammonium persulfate as the oxidant. The electrical, XPS and FTIR characterizations indicated that the amino acids co-doped the PPy backbone. TEM revealed that PPy presented a quasi-spherical morphology with diameters in nanometric scale. The nanostructures of PPy-glutamic acid efficiently adsorbed therapeutic doses of amoxicillin. Composite hydrogels were obtained by the entrapment of amoxicillin-loaded PPy in polyacrylamide network. The antibiotic molecules can be subsequently released (or sustained) from composite hydrogel in response to application (or removal) of electrical stimulation. This tuning release profile can lead to promising drug delivery applications such as implantable devices and iontophoretic systems. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41804
Template and target information: l-serine, l-glutamic acid, amoxicillin
Author keywords: conducting polymers, drug delivery systems, nanostructured polymers

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