MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Müller A, König B
Article Title: Preparation of luminescent chemosensors by post-functionalization of vesicle surfaces.
Publication date: 2015
Journal: Organic & Biomolecular Chemistry
Volume: 13
Issue: (6)
Page numbers: 1690-1699.
DOI: 10.1039/C4OB02327G

Abstract: Surface-reactive luminescent vesicles were prepared by self-assembly of phospholipids, amphiphilic maleimides and fluorophors in aqueous solution. Those preformed liposomes were functionalized with various thiolated receptor units using a thiol-click reaction. As recognition elements, a bis-Zn2+-cyclen derivative for the detection of phosphate moieties or a DNA aptamer for the specific binding of the antibiotic ampicillin were utilized. A FRET-based assay revealed the close spatial proximity of the membrane-embedded dansyl molecules with the subsequently immobilized thiols, which is the origin for the signaling mechanism of the obtained vesicular sensors. Those receptor-functionalized liposomes indicate the binding of the targets to their surface by changes of the fluorescence emission properties of the membrane co-embedded carboxyfluorescein dyes. The post-functionalization concept can also be used for molecular imprinting on vesicle surfaces. The template-guided patterning of receptors based on bis-Zn2+-cyclen resulted in fluorescent sensors suitable for the specific recognition of a bivalent peptide
Template and target information: peptide

  Live and Let MIP spoof movie poster bag  Chemistry peptide mug  Chemists are fun customisable shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner