MIPs logo MIPdatabase      Special issue call for papers   
Custom Search
Reference type: Journal
Authors: Zhu DW, Chen Z, Zhao KY, Kan BH, Li H, Zhang XX, Lin BB, Zhang LH
Article Title: Adsorption and sustained release of haemoglobin imprinted polysiloxane using a calcium alginate film as a matrix.
Publication date: 2015
Journal: RSC Advances
Volume: 5
Issue: (34)
Page numbers: 26977-26984.
DOI: 10.1039/C5RA03593G

Abstract: A calcium alginate (CA) hydrogel film was prepared by cross-linking sodium alginate (SA) with a CaCl2 solution. Haemoglobin (Hb) molecularly imprinted polysiloxane (MIP) was synthesized using silane as a functional monomer, Hb as a template and a CA hydrogel film as a matrix. SEM, TEM, TG and a water contact angle test were used to characterize the CA hydrogel and MIP film. The adsorption and recognition properties of MIPs were evaluated and the results showed that the MIP exhibited a significant improvement in terms of rebinding capacity for Hb compared with non-imprinted polysiloxane (NIP). Haemoglobin imprinted polysiloxane could selectively recognize the template protein from a mixture of other competitive proteins. The surface hydrophilicity and the swelling behaviour of the MIP film can be adjusted by changing the ratio of two types of silane. Hb was released from the MIP in a sustained manner in PBS and Tris-HCl solutions. The Higuchi model fits best for the MIP film no matter whether it is in PBS or in a Tris-HCl solution. It is a diffusion-controlled release mechanism for the MIP film. But diffusion is not the key factor for release of the NIP film
Template and target information: protein, haemoglobin, Hb

  Periodic table Coach hat  MIPs peptide mug  We need to talk about Kelvin shirt


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner