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Reference type: Journal
Authors: Martins MCG, Maia PP, Boralli VB, Figueiredo EC, Martins I
Article Title: Determination of Cotinine in Urine by Molecularly Imprinted Polymer Solid Phase and Liquid-Liquid Extraction Coupled with Gas Chromatography.
Publication date: 2015
Journal: Analytical Letters
Volume: 48
Issue: (8)
Page numbers: 1245-1256.
DOI: 10.1080/00032719.2014.979359

Abstract: A comparison between molecularly imprinted solid phase extraction (MISPE) and liquid-liquid extraction (LLE) was performed for cotinine in human urine followed by gas chromatography analysis. The molecularly imprinted polymer (MIP) was synthesized via bulk methodology employing cotinine, methacrylic acid, and ethylene glycol dimethacrylate as template, functional monomer, and cross-linker, respectively. Both methods were validated with good precision and accuracy. The LLE method (limit of quantification = 10 nanograms per milliliter) was slightly more sensitive than the MISPE (limit of quantification = 15 nanograms per milliliter) procedure, but both methods were able to determine cotinine at typical concentrations in urine. An important advantage of the molecularly imprinted polymer approach was its ability to be reused up to at least 100 times. Other advantages of the MISPE include simple manipulation, low solvent consumption, and low worker exposure
Template and target information: cotinine
Author keywords: Cotinine, gas chromatography, Liquid-liquid extraction, molecularly imprinted polymer


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