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Reference type: Journal
Authors: Liu YB, Fang SM, Zhai JQ, Zhao MP
Article Title: Construction of antibody-like nanoparticles for selective protein sequestration in living cells.
Publication date: 2015
Journal: Nanoscale
Volume: 7
Issue: (16)
Page numbers: 7162-7167.
DOI: 10.1039/C4NR07615J

Abstract: We demonstrate the successful construction of fluorescently labeled magnetic antibody-like nanoparticles (ANPs) via a facile one-step surface-initiated in situ molecular imprinting approach over silica coated magnetite (Fe3O4@SiO2) core-shell nanocomposites. The as-prepared ANPs had a highly compact structure with an overall size of 83 5 nm in diameter and showed excellent aqueous dispersion stability. With the predetermined high specificity to the target protein and high biocompatibility, the ANPs enabled rapid, efficient, selective and optically trackable sequestration of target proteins within living cells. This work represents the first example of fully artificially engineered multifunctional ANPs for the intracellular protein-sequestration without disruption of the cells. The established approach may be further extended to generate ANPs for various proteins of interest and provide useful tools for related biological research and biomedical applications
Template and target information: protein, DNase I


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