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Abstract: A novel method was developed for the determination of cyproheptadine in feeds using molecularly imprinted solid-phase extraction coupled with high-performance liquid chromatography. The polymers were prepared using cyproheptadine as a template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linking agent, and dichloromethane as a solvent by bulk polymerization. Under the optimum solid-phase extraction conditions, the molecular imprinting cartridge can selectively extract and enrich cyproheptadine from a variety of feeds. Mean recoveries of cyproheptadine from four kinds of feeds spiked at 0.1, 1.0 and 10 mg kg-1 ranged from 85.5% to 96.2%, with intra-day and inter-day relative standard deviation less than 10%. The calibration curve of cyproheptadine was good linear relationship (r > 0.9993) within the range of 0.1-50 μg mL-1. The limit of detection (LOD) and the limit of quantification (LOQ) were 0.04 and 0.1 mg kg-1, respectively
Template and target information: cyproheptadine
Author keywords: Molecularly imprinted polymers, Cyproheptadine, high performance liquid chromatography, Feeds