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Reference type: Journal
Authors: Gu XL, He HL, Wang CZ, Gao YK, Zhang HJ, Hong JL, Du SH, Chen LN, Yuan CS
Article Title: Synthesis of surface nano-molecularly imprinted polymers for sensitive baicalin detection in biological samples.
Publication date: 2015
Journal: RSC Advances
Volume: 5
Issue: (52)
Page numbers: 41377-41384.
DOI: 10.1039/C5RA04424C

Abstract: Surface molecularly imprinted polymers (MIP@SBA-15) imprinted on the surface of hybrid nanostructured organic/inorganic materials (SBA-15) were prepared for the selective extraction and detection of baicalin (BA) in biological samples. The surface morphologies and characteristics of the imprinted and non-imprinted polymers were characterized by Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TGA) and nitrogen adsorption-desorption isotherms. The results indicated that the polymers were successfully grafted onto the surface of SBA-15 and possessed a highly ordered mesoporous structure. In binding tests, MIP@SBA-15 reached saturated adsorption within 80 min and exhibited significant specific recognition toward BA with a large adsorption capacity. In addition, the prepared MIP@SBA-15 was used as a selective sorbent for solid-phase extraction of BA from biological samples. Recoveries of BA from the liver and spleen ranged from 90.6% to 90.9% with RSD <3.7%. All these results reveal that this method is simple, rapid and sensitive for effectively extracting and detecting trace BA in biological samples
Template and target information: baicalin, BA

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