Authors: Boos KS
, Fleischer CT
Bioanalytical solid-phase extraction: A classic in a new, tailor-made garment.
Publication date: 2001
Abstract: In bioanalytical HPLC, optimization of sample pretreatment should be directed towards improved selectivity, high sample through-put and total automation with simultaneous cost- reduction and improvment of the analytical quality. These requirements can be accomplished by integrating the extractive sample cleanup process (Solid-Phase Extraction; SPE) into the HPLC-system For this purpose, tailor-made adsorbents (Restricted Access Materials, RAM; Molecular Imprinted Polymers, MIP) are used as precolumn packings
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