MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: Moein MM, Javanbakht M, Karimi M, Akbari-Adergani B, Abdel-Rehim M
Article Title: Three-phase molecularly imprinted sol-gel based hollow fiber liquid-phase microextraction combined with liquid chromatography-tandem mass spectrometry for enrichment and selective determination of a tentative lung cancer biomarker.
Publication date: 2015
Journal: Journal of Chromatography B
Volume: 995-996
Page numbers: 38-45.
DOI: 10.1016/j.jchromb.2015.05.005
Alternative URL: http://www.sciencedirect.com/science/article/pii/S1570023215300039

Abstract: In the present study, the modification of a polysulfone hollow fiber membrane with in situ molecularly imprinted sol-gel process (as a novel and one-step method) was prepared and investigated. 3-(propylmethacrylate)trimethoxysilane (3PMTMOS) as an inorganic precursor was used for preparation of molecularly imprinted sol-gel. The modified molecularly imprinted sol-gel hollow fiber membrane (MSHM) was used for the liquid-phase microextraction (LPME) of hippuric acid (HA) in human plasma and urine samples. MSHM as a selective, robust, and durable tool was used for at least 50 extractions without significant decrease in the extraction efficiency. The non-molecularly imprinted sol-gel hollow fiber membrane (NSHM) as blank hollow fiber membrane was prepared by the same process, only without HA. To achieve the best condition, influential parameters on the extraction efficiency were thoroughly investigated. The capability of this robust, green, and simple method for extraction of HA was successfully accomplished with LC/MS/MS. The limits of detection (LOD) and quantification (LOQ) in human plasma and urine samples were 0.3 and 1.0 nmol L-1, respectively. The standard calibration curves were obtained within the concentration range 1-2000 nmol L-1 for HA in human plasma and urine. The coefficients of determination (r2) were 0.998. The obtained data exhibited recoveries were higher than 89% for the extraction of HA in human plasma and urine samples
Template and target information: hippuric acid, HA
Author keywords: Molecularly imprinted polymers, sol-gel, Hollow fiber membrane, hippuric acid, Liquid phase microextraction, mass spectrometry

  Periodic table Trainer shirt  Imprinting peptide mug  We need to talk about Kelvin shirt

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner