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Reference type: Journal
Authors: Hussain M
Article Title: Ultra-sensitive detection of heparin via aPTT using plastic antibodies on QCM-D platform.
Publication date: 2015
Journal: RSC Advances
Volume: 5
Issue: (68)
Page numbers: 54963-54970.
DOI: 10.1039/C5RA08066E
Alternative URL: http://www.researchgate.net/profile/Munawar_Hussain8/publication/279312172_Ultra-sensitive_detection_of_heparin_via_aPTT_using_plastic_antibodies_on_QCM-D_platform/links/55c78dbc08aebc967df879aa.pdf

Abstract: One of the challenges faced by today's clinics is unavailability of practical, precise and accurate determination of the most commonly used anti-coagulant 'heparin' in human blood/plasma in surgery. This is the first report of the application of a heparin imprinted thin film on a Quartz Crystal Microbalance with Dissipation (QCM-D) platform. Based on a novel, straight-forward and robust imprinting approach, a lowest volume consumption of 2 [small mu ]L of real sample (of human plasma) has been demonstrated. This is a leap for launching spot testing for heparin sensing in laboratory practice. This approach could shorten the coagulation times to 48% and 45% for clinically important sensing range of heparin doses of 0.75 and 0.50 IU mL-1 respectively and could improve precision 3-fold (n = 20 samples) compared to that of today's 'gold standard'. Activated partial thromboplastin time (aPTT) on the plastic antibodies based QCM-D platform for plasma with doses of heparin 0.75 IU mL-1 and 0.50 IU mL-1 yielded 6.5% and 5% lower %RSD respectively as compared to that of the 'gold standard'. The present studies could provide a launch pad to laboratory methods for ultra-refining of point of care (POC) settings in the perspectives of coagulation time shortening, precision of the method and sample volume consumption
Template and target information: heparin


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