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Reference type: Book Chapter
Authors: Miyata T
Publication date: 2015
Chapter title: Target Biomolecule-responsive Hydrogels.
Chapter number: 15
Page numbers: 408-443.
DOI: 10.1039/9781782622420-00408

Book title: Chemoresponsive Materials: Stimulation by Chemical and Biological Signals
Editors: Schneider HJ
Publisher: The Royal Society of Chemistry
ISBN: 978-1-78262-062-4
Series title: RSC Smart Materials
Series editors: Schneider HJ, Shahinpoor M
Volume number: 14

Abstract: Stimuli-responsive hydrogels have attracted much attention as smart biomaterials for drug delivery systems, sensors, cell culture and so on. Target biomolecule-responsive hydrogels that undergo changes in volume in response to a specific biomolecule have many potential applications in biochemical and biomedical fields because biomolecules such as saccharides and proteins are useful signals for site-specific drug delivery systems or for diagnosis to monitor several physiological changes. However, there have not been so many reports on biomolecule-responsive hydrogels in spite of their many potential applications because of difficulties in effective combinations of biomolecular recognition events with responsive network changes. This chapter provides an overview of important studies on target biomolecule-responsive hydrogels that recognize a specific biomolecule and that induce structural changes as a function of its concentration. In this chapter, various biomolecule-responsive hydrogels are classified by the kinds of target biomolecules and mechanisms for responsive behaviors. The fascinating properties of biomolecule-responsive hydrogels can provide the tools for creating functional biomaterials and biomedical systems with a wide variety of uses. Some studies described in this chapter can surely lead to not only a better understanding of the structures and functions of biomolecule-responsive hydrogels but also useful strategies to develop novel stimuli-responsive hydrogels as smart biomaterials.
Template and target information: Review - biomolecule responsive hydrogels


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