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Abstract: Super paramagnetic molecularly imprinted polymers can be specific recognition towards target molecules and fast separate from solution. In present article, an inexpensive and selective recognition of thymopentin method was introduced. A library of 27 kinds of common functional monomers for preparing molecular imprinted polymer (MIP) was built and their interactions with template thymopentin were calculated using the molecular dynamics software (materials studio 5.5). According to the theoretical calculation results, N,N'-methylene bisacrylamide was selected as functional monomer to form a stable pre-polymerization complex. The Fe3O4-MIPs were prepared by thymopentin as template, Fe3O4-Br as initiator, CuCl as catalyst, N,N,N',N',N''-pentamethyldiethylenetriamine as ligand, EGDMA as cross-linker in ethanol and water through atom transfer radical polymerization at 50 °C. The molecular recognition of thymopentin was analyzed by using molecular modeling software (materials studio 5.5).
Template and target information: thymopentin
Author keywords: Molecularly imprinted polymers, Thymopentin, Molecular dynamics simulation, molecular recognition