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Reference type: Journal
Authors: Zhang K, Zou WY, Zhao HY, Dramou P, Pham-Huy C, He J, He H
Article Title: Adsorption behavior of a computer-aid designed magnetic molecularly imprinted polymer via response surface methodology.
Publication date: 2015
Journal: RSC Advances
Volume: 5
Issue: (75)
Page numbers: 61161-61169.
DOI: 10.1039/C5RA10367C

Abstract: A novel magnetic molecularly imprinted polymer (MMIP) has been designed using flexible docking and molecular dynamics in computer simulation. Six kinds of representative functional monomers have been screened to obtain the optimal one, as well as optimizing its ratio to the template amlodipine (AML). Two MMIPs have been prepared with the most suitable functional monomer methacrylic acid (MAA) along with acrylamide (AM) as a comparison, in the ratio of 4 to AML. Fourier transform infrared (FT-IR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and vibrating sample magnetometery (VSM) were used to characterize the structure, morphology and magnetic properties of the MMIPs. A static adsorption study was carried out with the help of response surface methodology (RSM) and in addition, adsorption kinetics and isotherms were studied to further explain the adsorption behavior. Three dihydropyridine calcium channel blockers (DHP-CCBs) as structural analogues and non-structural analogue penicillin V potassium were chosen for the selectivity study. The results showed that MMIP using MAA as functional monomer had a large adsorption capacity (53.77 μg mg-1) as well as a large imprinting factor (more than 2) and the adsorption behavior was in accordance with a pseudo-second-order model and Freundlich isotherm model. Due to the excellent properties of the polymer: good magnetic properties, large adsorption capacity and great selectivity for DHP-CCBs, a magnetic molecularly imprinted solid phase extraction with ultraviolet detection (M-MISPE-UV) method had been established, validated and applied to the analysis of AML in urine sample
Template and target information: amlodipine, AML

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