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Reference type: Book Chapter
Authors: Takeuchi T, Sunayama H, Takano E, Kitayama Y
Publication date: 2015
Chapter title: Post-imprinting and In-Cavity Functionalization.
Chapter number: 4
Page numbers: 95-106.
DOI: 10.1007/10_2015_314 Alternative URL: http://www.springer.com/978-3-319-20728-5

Book title: Molecularly Imprinted Polymers in Biotechnology
Editors: Mattiasson B, Ye L
Publisher: Springer
City: Berlin,Heidelberg
ISBN: 978-3-319-20728-5
Series title: Advances in Biochemical Engineering/Biotechnology

Abstract: Molecularly imprinted polymers (MIPs) are artificial materials capable of molecular recognition for target molecules. Currently MIPs have been prepared without further modification after polymerization, and used for predetermined single purposes. Post-imprinting modifications (PIMs) presented here can provide site-specific modifications within the molecularly imprinted binding cavities after polymerization, enabling MIPs to become more complex functional materials as were the cases of naturally occurring conjugated proteins. We present an overview of the research on MIPs involving PIMs, including transformation of binding sites, on/off switching of binding activity, introduction of desirable functions such as fluorescent signalling functions, catalytic activity, and so on. The combination of PIMs with molecular imprinting appears to be a powerful tool for preparing a diverse range of biomimetic functional materials
Template and target information: Review - MIPs post functionalization
Author keywords: artificial receptor, molecularly imprinted polymer, Post-imprinting modification, protein mimics, Reconstruction of binding cavity, Tunable binding sites


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