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Reference type: Journal
Authors: Shumyantseva VV, Bulko TV, Baychorov IK, Archakov AI
Article Title: Molecularly imprinted polymers in electro analysis of proteins.
Publication date: 2015
Journal: Biomeditsinskaya Khimiya
Volume: 61
Issue: (3)
Page numbers: 325-331.
DOI: 10.18097/PBMC20156103325
Alternative URL: http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-2015-61-3-325-en

Abstract: In the review the main approaches to creation of recognition materials capable of competing with biological specific receptors, (polymeric analogs of antibodies or molecularly imprinted polymers, MIP) for the electro analysis of functionally significant proteins such as a myoglobin, troponin T, albumin, human ferritin, calmodulin are considered. The main types of monomers for MIP fabrication, and methods for MIP/protein interactions, such as a surface plasmon resonance (SPR), nanogravimetry with use of the quartz crystal resonator (QCM), spectral and electrochemical methods are discussed. Experimental data on electrochemical registration of a myoglobin using MIP/electrode are presented. For a development of electrochemical sensor systems based on MIPs, o-phenylenediamine (1,2-diaminobenzene was used as a monomer. It was shown that the imprinting factor Imax(MIP)/Imax(NIP), calculated as a myoglobin signal ratio when embedding in MIP to a myoglobin signal when embedding in the polymer received without molecular template (NIP) corresponds 2-4.
Template and target information: Review - MIPs in electroanalysis of proteins


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