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Reference type: Journal
Authors: Jalili R, Amjadi M
Article Title: Surface molecular imprinting on silane-functionalized carbon dots for selective recognition of nifedipine.
Publication date: 2015
Journal: RSC Advances
Volume: 5
Issue: (90)
Page numbers: 74084-74090.
DOI: 10.1039/C5RA12189B

Abstract: This study describes the development of a novel eco-friendly molecularly imprinted fluorescent sensor for nifedipine (NIF) based on silane-functionalized carbon dots (MIP@SiC-dots). The sensor was synthesized by a sol-gel reaction (imprinting process) and characterized by fluorescence spectroscopy, UV-vis spectroscopy, TEM, SEM and FT-IR. The fluorescence from the MIP@SiC-dots was quenched more strongly by NIF as compared to the non-imprinted polymer. This indicates that the MIP-coated SiC-dots, which act as a fluorescence sensing material, can recognize NIF. Under optimized operational conditions, a linear response was obtained in the concentration range from 0.28 to 3.4 μM with a detection limit of 0.076 μM. The proposed sensor was applied for NIF determination in serum and urine samples with the recoveries from 94.2% to 105.6%, showing promising potential applications in biomedical analysis
Template and target information: nifedipine, NIF

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